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K-Botulinum Toxin,
Nabota®

Nabota® is a high-purity botulinum toxin that became the first in Asia to receive approval from the U.S. FDA. It has established partnerships in approximately 80 countries and obtained regulatory approvals in 67 countries. Based on this, Nabota® is a global toxin currently marketed in around 40 countries worldwide.

K-Botulinum Toxin, <br class='pc' />Nabota®

High‑Purity Manufacturing Process

Through Daewoong Pharmaceutical’s proprietary HYPERPURE™ process, unnecessary complex proteins other than the neurotoxin are minimized, ensuring high purity and safety. This helps reduce the risk of adverse events and enables predictable treatment outcomes.

Flexible Dose Options

A range of dose options—50U, 100U (approved by the U.S. FDA and EMA), and 200U (approved in Korea)—allows for optimal selection based on patient condition and treatment area.

Global Market Competitiveness

As the first botulinum toxin product from Korea to receive U.S. FDA approval, Nabota® has also been approved by the EMA and is authorized in more than 67 countries worldwide, demonstrating its quality and competitiveness.

Expanded Indications

Beyond aesthetic use, indications are being steadily expanded into various therapeutic areas, including upper limb spasticity following stroke and blepharospasm. Additional indications are expected to expand in line with clinical development progress.

  • [Korea / Global] Glabellar lines, Post‑stroke upper limb spasticity, Crow’s feet, Blepharospasm, Masseter hypertrophy
  • [Indonesia] Glabellar lines
  • [Indications under clinical development] Chronic migraine, Cervical dystonia, Gastroparesis, Post‑traumatic stress disorder (PTSD)

* Marketing authorization granted by the Indonesian regulatory authority (2019)

Next-Generation Toxin Formulations

  • Liquid Formulation
    Liquid Formulation

    Developed as a ready-to-use liquid formulation without a lyophilization process, it significantly reduces preparation time by eliminating the need for reconstitution. Consistent drug concentration enhances convenience and accuracy during treatment.

  • Microneedle Delivery System
    Microneedle Delivery System

    Utilizing ultra-fine needles designed to minimize pain, the drug is precisely delivered into the superficial layers of the skin. This reduces procedural burden for patients and enables new applications in aesthetic treatments.

  • Long-Acting Formulation
    Long-Acting Formulation

    Compared to conventional toxins, the duration of effect is significantly extended, allowing for longer treatment intervals and reducing the need for repeated procedures. Patients can maintain satisfactory results for longer.

  • Low-Immunogenic Toxin
    Low-Immunogenic Toxin

    This next-generation toxin is designed to reduce the risk of antibody formation and resistance that may occur with repeated treatments. It enables more stable and consistent long-term outcomes, thereby improving patient adherence.

Aesthetic & Cosmetic Portfolio

  • 01 HA Fillers

    HA fillers are composed of hyaluronic acid, a substance similar to components naturally found in the human body, with high biocompatibility. They provide immediate volumizing effects, primarily for deep facial wrinkles and areas of volume loss. In addition to improving deep wrinkles unrelated to muscle contraction, HA fillers help restore facial contours and enhance volume in a natural-looking manner.

  • 02 Skin Boosters

    Skin boosters provide anti-aging and skin regeneration benefits. By delivering hydration and nutrients directly into the dermal layer, they promote collagen production and contribute to improved skin elasticity, wrinkle reduction, and overall skin texture. By restoring intrinsic skin health, they improve deep wrinkles unrelated to muscle contraction and support overall anti-aging benefits.

Indications & Applications

  • Aesthetic
    Aesthetic

    Botulinum toxin contributes to improved aesthetic outcomes by reducing wrinkles and refining facial contours.

    • Glabellar Lines

      Softens expression lines to create a smoother facial appearance (approved by the U.S. FDA and EMA)

    • Crow’s Feet

      Improves fine lines around the eyes for a more youthful appearance (approved in Korea)

    • Masseter Reduction

      Creates a slimmer jawline by reducing the masseter muscle (benign masseter hypertrophy; first approval globally in August 2023)

  • Therapeutic
    Therapeutic

    Botulinum toxin effectively relieves muscle tension and spasticity caused by neurological disorders, improving patients’ quality of life.

    • Post-Stroke Upper Limb Spasticity

      Reduces spasticity in the arm and hand, supporting functional recovery and pain reduction (approved in Korea)

    • Blepharospasm

      Suppresses involuntary eyelid spasms, improving visual function and relieving discomfort (benign essential blepharospasm; approved in 2019)

Core Competency

Defining new paradigms in treatment through advanced technology and differentiated research
Core Competency
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Core Competency 01

Proprietary High-Purity Purification Technology

Proprietary High-Purity Purification Technology

Daewoong Pharmaceutical’s HI-PURE Technology minimizes unnecessary complex proteins other than the neurotoxin, ensuring high purity and safety. This helps reduce the risk of adverse events and contributes to predictable treatment outcomes.

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Core Competency 02

Manufacturing Process Aligned with Global Quality Standards

Manufacturing Process Aligned with Global Quality Standards

Daewoong Pharmaceutical has established a manufacturing system that meets stringent global quality standards, including U.S. cGMP and EU regulatory requirements. Based on advanced technological capabilities, Nabota® is produced with consistent high quality and supplied reliably to global markets.

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Core Competency 03

Next-Generation Formulations and Aesthetic R&D Capabilities

Next-Generation Formulations and Aesthetic R&D Capabilities

Daewoong Pharmaceutical is developing next-generation formulations based on botulinum toxin, while also building a broad portfolio of aesthetic products—including V-OLET™, fillers, and skin boosters—applicable to both aesthetic and therapeutic procedures. In the aesthetics segment, the company strengthens its brand package strategy to deliver premium aesthetic solutions tailored to diverse customer needs.

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Core Competency 04

Extensive Experience with Global Regulatory Approvals

Extensive Experience with Global Regulatory Approvals

Daewoong Pharmaceutical became the first in Korea to receive U.S. FDA approval and has obtained regulatory approvals in more than 67 countries worldwide, including in the EU. This experience and expertise play a critical role in market expansion and product portfolio growth.

R&D·Tech | DAEWOONG